GRGDS 是骨桥蛋白中识别 avb3 整合素的细胞黏附序列。骨桥蛋白在恶性肿瘤的实验模型中过度表达。尽管骨桥蛋白的天然形式在细胞黏附试验中具有活性，但已观察到凝血酶对骨桥蛋白的切割会显著增强其黏附特性。这种切割发生在 GRGDS 序列的残基内，这增加了凝血酶切割进一步通过使 GRGDS 结构域更易接近细胞表面受体而激活骨桥蛋白的可能性。GRGDS 合成肽还模拟了细胞外基质中许多黏附蛋白的细胞结合位点，并导致铺展细胞的圆化和脱落。它诱导α-辅肌动蛋白和连环蛋白从粘着斑部位解离。

GRGDS is the cell adhesion sequence of osteopontin that recognizes the avb3 integrin. Osteopontin is overexpressed in experimental models of malignancy. Although the native form of OPN is active in cell attachment assays, it has been observed that thrombin cleavage of OPN causes substantial enhancement of it's attachment properties. This cleavage occurs within residues of the GRGDS sequence raising the possibility of thrombin-cleavage further activating OPN by allowing greater accessibility of the GRGDS domain to cell surface receptors. GRGDS synthetic peptide also mimics the cellular binding site of many adhesive proteins in the extracellular matrix and causes rounding and detachment of spread cells. It induces dissociation of alpha-actinin and vinculin from the sites of focal contacts.

单字母 H2N-GRGDS-OH

CAS号：91037-71-7
多字母 H2N-Gly-Arg-Gly-Asp-Ser-OH
氨基酸个数 5
分子式 C17H30N8O9
平均分子量(MW) 490.47
精确分子量(Exact Mass)(MW) 490.21
等电点(PI) 10.56
pH=7.0时的净电荷数 0.98
GRAVY -1.92
亲水残基比例 0.14
消光系数 -
溶解建议 非常亲水

参考文献：
Senger DR, Perruzzi CA. Cell migration promoted by a potent GRGDS-containing thrombin-cleavage fragment of osteopontin. Biochim Biophys Acta. 1996 Nov 8;1314(1-2):13-24. doi: 10.1016/s0167-4889(96)00067-5. PMID: 8972713.