Tat-CIRP 是一种源自冷诱导 RNA 结合蛋白（CIRP）高亲和力结合区的肽，它能竞争性地与髓样分化因子 2（MD2）结合，从而阻断 MD2 与 CIRP 的相互作用。MD2 是激活 Toll 样受体 4（TLR4）所必需的辅助蛋白，用 Tat-CIRP 阻断 MD2 和 TLR4 的功能具有神经保护作用，在体外可减少细胞凋亡和坏死性凋亡。在体内，Tat-CIRP 对小鼠的缺血性和出血性中风具有神经保护作用，并且在恒河猴缺血性中风 30 天后可减少脑梗死体积并保护神经功能。

Tat-CIRP is a peptide derived from the high affinity binding region of cold-inducible RNA binding protein (CIRP) which competitively binds to myeloid differentiation factor 2 (MD2) and blocks the MD2-CIRP interaction. MD2 is an essential accessory protein for Toll like receptor 4 (TLR4) activation and blocking the function of MD2 and TLR4 with Tat-CIRP is neuroprotective, reducing apoptosis and necroptosis in vitro. In vivo, Tat-CIRP is neuroprotective against ischemic and hemorrhagic stroke in mice and reduces brain infarct volume and preserves neurological function in rhesus monkeys 30 days after ischemic stroke.

单字母 H2N-YGRKKRRQRRRGRGFSRGGGDRGYGG-OH
多字母 H2N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly-OH
氨基酸个数 26
分子式 C123H206N56O33
平均分子量(MW) 2997.31
精确分子量(Exact Mass)(MW) 2995.62
等电点(PI) 13.41
pH=7.0时的净电荷数 12.97
GRAVY -2.26
亲水残基比例 0.04
消光系数 2980
溶解建议 亲水

参考文献：
Fang et al (2021) An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke. Sci Transl Med. 13(597) eabb6716 PMID: 34108252