MAGE-A4（286 - 294）在体外能从 HLA-A*0201 阳性的外周血单个核细胞（PBMCs）中诱导出肽特异性细胞毒性 T 淋巴细胞（CTLs），并且在 HLA-A*0201/K(b) 转基因小鼠体内也能诱导出 CTLs。诱导出的 CTLs 能够以 HLA-A*0201 限制的方式裂解靶细胞，这表明这两个肽是 HLA-A*0201 限制的 CTL 表位，可作为治疗性抗肿瘤疫苗的靶点。

MAGE-A4(286-294) could elicit peptide-specific CTLs both in vitro from HLA-A*0201-positive PBMCs and in HLA-A*0201/K(b) transgenic mice. And the induced CTLs could lyse target cells in an HLA-A*0201-restricted fashion, demonstrating that the two peptides are HLA-A*0201-restricted CTL epitopes and could serve as targets for therapeutic antitumoral vaccination.

单字母 H2N-KVLEHVVRV-OH
多字母 H2N-Lys-Val-Leu-Glu-His-Val-Val-Arg-Val-OH
氨基酸个数 9
分子式 C49H87N15O12
平均分子量(MW) 1078.31
精确分子量(Exact Mass)(MW) 1077.67
等电点(PI) 11.66
pH=7.0时的净电荷数 2.21
GRAVY 0.61
亲水残基比例 -
消光系数 -
溶解建议 亲水

参考文献：

Jia ZC, Ni B, Huang ZM, Tian Y, Tang J, Wang JX, Fu XL, Wu YZ. Identification of two novel HLA-A*0201-restricted CTL epitopes derived from MAGE-A4. Clin Dev Immunol. 2010;2010:567594. doi: 10.1155/2010/567594. Epub 2011 Feb 14. PMID: 21350607; PMCID: PMC3042617.