st-Ht31是肽Ht-31的硬脂酸形式，是由24个氨基酸和N端的硬脂酸组成的直链多肽，能抑制细胞提取物中cAMP依赖性PKA的RII亚基与 A 激酶锚定蛋白 (AKAP) 之间的相互作用，在细胞内可渗透。 st-Ht31 ammonium 是一种蛋白激酶 A (PKA) 锚定的膜渗透肽抑制剂。st-Ht31 ammonium 诱导强烈的胆固醇/磷脂流出。st-Ht31 ammonium 完全逆转泡沫细胞形成并恢复巨噬细胞的代谢健康。 st-Ht31 (5 μM; 2 h) ammonium enhances cholesterol/phospholipid efflux in BHK cells and RAW macrophages[1]. st-Ht31 (10μM; 24 h) ammonium reverses foam cell formation and restores metabolic health of macrophage[1]. st-Ht31 (20 μM; 20 min) ammonium abolishes the cAMP inhibition of PMA-induced ERK1/2 activation n HEK293T cells[2]. 中文名称: Ht-31硬脂酸多肽、st-Ht31 英文名: st-Ht31、Ht-31 单字母: Stearoyl-DLIEEAASRIVDAVIEQVKAAGAY-OH 三字母: Stearoyl-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr-OH 氨基酸个数: 24 分子式: C129H217O39N29 平均分子量: 2798.27 精确分子量: 2796.59 等电点(PI): 4.2 pH=7.0时的净电荷数: -2 平均亲水性: 0.14782608695652 疏水性值: 0.38
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参考文献：
Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1【DOI: 10.1074/jbc.M110.173666】 A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa【 DOI: 10.1038/srep37922】
