Ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)])包含了两个amyloid β-蛋白16到20个氨基酸的全D型序列klvff。包含两个全D型序列klvff的ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)])对amyloid β-protein (1-40)纤维质的亲和力(Kd = 1.3 · 10-2 µM)比KLVFF (Kd = 1.1 ± 0.3 µM)高出大概100倍。 另外,根据ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)])对硫黄素T结合到β-折叠结构抑制能力的增强判断,ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)])比KLVFF对有序纤维质形成的抑制效果更强。
序列(三字母):H-DPhe-DPhe-DVal-DLeu-DLys-β-Ala-DLys(DLys-DLeu-DVal-DPhe-DPhe-H)-OH
序列(单字母):ffvlk-β-Ala-DLys(klvff)-OH
别名:ent-[retro-Amyloid β-Protein (16-20)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)]), (ffvlk)₂(βA)k (tandem dimer)
分子式:C79H119N15O13
分子量:1486.91
CAS#:1426174-31-3
合成方法:Synthetic
存储条件:-20 °C,避光,干燥
应用:Alzheimers Disease