(7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid β-Protein (1-40)是amyloid β-protein (1-40) N-端修饰了荧光香豆素D1421(DAC或者DEAC, CAS#: 50995-74-9)的序列。(7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid β-Protein (1-40)跟amyloid β-protein (1-40)具有非常相似的性质，因此它可以被用来评估amyloid β-protein (1-40)和各种细胞膜的结合性质。在有水环境中，(7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid β-Protein (1-40)的荧光基团是没有荧光的，但是跟细胞膜结合之后，其荧光强度会增强(λex = 430 nm, λem = 470 nm)。在脂质双分子层中增加神经节苷脂GM1和胆固醇含量可以促进(7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid β-Protein (1-40)多肽的结合。胆碱和磷脂酰丝氨酸没有发现有亲和性。

序列(三字母)：(7-Diethylaminocoumarin-3-yl)carbonyl-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
序列(单字母)：(7-Diethylaminocoumarin-3-yl)carbonyl-DAEFRHDSGYEVHHQKLVFFAEDVGSAKGAIIGLMVGVV
分子式:C208H308N54O61S
分子量:4573.13
CAS#:1802087-66-6
合成方法：Synthetic
存储条件：-20 °C，避光，干燥
应用：Alzheimers Disease