Polyphemusin II-Derived Peptide别名T140,通过与趋化因子受体CXCR4 (IC50 = 0.18 ± 0.041 nM)特异性结合,显示出最高的抗亲T细胞链HIV感染抑制活性,对anti-CXCR4单克隆抗体结合到CXCR4显示出了最强的抑制作用(IC50 = 2.3 ± 0.20 nM)。
序列(三字母):H-Arg-Arg-2-Nal-Cys-Tyr-Arg-Lys-D-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-OH (Disulfide bond)
序列(单字母):RR-2-Nal-CYRKkPYR-Cit-CR
别名:T140
分子式:C90H141N33O18S2
分子量:2037.45
CAS#:229030-20-0
合成方法:Synthetic
存储条件:-20 °C,避光,干燥
应用:Infectious Disease
参考文献:
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption【DOI: 10.1021/jm9803065】