Neurokinin A TFA (Substance K TFA) 是速激肽家族的一种肽类神经递质,通过NK-2受体发挥作用。在人气道和胃肠道组织中作为主要的介体。
体外研究:
Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].
单字母 H2N-HKTDSFVGLM-CONH2
CAS No. : 2828433-19-6
中文名称:神经激肽 A
多字母 H2N-His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-CONH2
氨基酸个数 10
分子式 C50H80N14O14S1
平均分子量(MW) 1133.32
精确分子量(Exact Mass)(MW) 1132.57
等电点(PI) 9.71
pH=7.0时的净电荷数 1.21
GRAVY 0.02
亲水残基比例 0.08
消光系数 -
溶解建议 疏水