Amylin, amide, human 是一种 37 个氨基酸的多肽，是一种与胰岛素共分泌的胰腺激素，在代谢和葡萄糖稳态中发挥独特作用。Amylin, amide, human 抑制胰高血糖素分泌，延迟胃排空，并作为饱腹感剂。

体外研究：

MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC50 of 35.2±7.5 nM[1].

体内研究：

Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min

单字母 H2N-KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-CONH2(Disulfide Bridge:C2-C7)

CAS No. : 122384-88-7
多字母 H2N-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-CONH2(Disulfide Bridge:Cys2-Cys7)
氨基酸个数 37
分子式 C165H261N51O55S2
平均分子量(MW) 3903.28
精确分子量(Exact Mass)(MW) 3900.86
等电点(PI) -
pH=7.0时的净电荷数 6.15
GRAVY -0.09
亲水残基比例 -
消光系数 1490
溶解建议 疏水

参考文献：

Monoconjugation of Human Amylin with Methylpolyethyleneglycol【 DOI: 10.1371/journal.pone.0138803】