Neurotensin 神经降压素是一种肠十三肽，作为有效的细胞有丝分裂原，作用于各种结肠直肠癌和胰腺癌，对神经降压素受体 (neurotensin receptor，NTR) 具有高亲和力。

体外研究：

Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca2+]i), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin[1].

单字母 Pyr-LYENKPRRPYIL-OH

CAS No. : 39379-15-2
多字母 Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
氨基酸个数 12
分子式 C78H121N21O20
平均分子量(MW) 1672.92
精确分子量(Exact Mass)(MW) 1671.91
等电点(PI) 12.53
pH=7.0时的净电荷数 4
GRAVY -1.07
亲水残基比例 -
消光系数 2980
溶解建议