740 Y-P TFA是一个有效的，具有细胞渗透性的PI3K激活剂。740 Y-P TFA很容易结合含有p85的 N- 和 C- 末端 SH2 结构域的 GST 融合蛋白，但不能单独结合 GST。

体外研究：

740 Y-P TFA (50 μg/ml; 48 hours) specificly stimulates mitogenesis in medium is better than EGF or FGF at stimulating entry into S-phase, it shows the percentage of cells in S-phase for 48.3% in C2 cells. Additionally, LY294002 or wortmannin potently inhibits the mitogenic response stimulated by the 740 Y-P TFA peptide[1].
740 Y-P TFA (1 μg/mL) stimulates mitogenesis at the lowest concentration tested. The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%), and in the former instance a maximal response observed at 50 μg/mL. 740Y-P to stimulate mitogenesis is highly specific and not a general feature of a cell permeable SH2 domain binding peptides[1].
740 Y-P TFA (30 μM; 24 hours) remarkably inhibits the level of LC3-II/LC3-I in GO-induced PC12 cells[2].

三字母：Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-Tyr(PO2)-Met-Asp-Met-Ser

单字母：RQIKIWFQNRRMKWKKSDGG-{PO2Y}-MDMS
分子量：3270.70 (free acid)

分子式：C141H222N43O39PS3.xC2HF3O2