1030384-98-5
2024/12/16 14:54:50
CTCE-9908 是一种有效的，选择性的CXCR4抑制剂。CTCE-9908在表达 CXCR4的卵巢癌细胞中诱导有丝分裂突变，诱导细胞毒性，抑制迁移。
CTCE-9908 (0-300 μg/mL; for 10 d) inhibits migration and growth in CXCR4-expressing in ovarian cancer cell lines (IGROV, TOV21G and SKOV3). CTCE-9908 inhibits ovarian cancer cell migration to CXCL12. CTCE-9908 does not cause apoptosis or cellular senescence, but induces multinucleation, G2-M arrest, and abnormal mitosis in ovarian cancer cells. CTCE-9908 deregulates DNA damage checkpoint proteins and spindle assembly checkpoint proteins at G2-M phases of the cell cycle。
CTCE-9908 (25, 50 and 100 mg/kg; s.c.; 5 days per week for 4.5 weeks) alone slows the rate of primary breast tumor growth, with a 45% inhibition of primary tumor growth at 3.5 weeks of treatment with 50 mg/kg in FVB/N TgN (MMTV-PyMT)634 male mice[2].
序列：1:KGVSLSYRK-NH2;Sequence 1':KGVSLSYR (Amide bridge:Lys9-Arg8’)
分子量：1927.25
分子式：C86H147N27O23
CAS 号：1030384-98-5
来源:人工化学合成，仅限科学研究使用，不得用于人体。
纯度: 95%、98%
盐体系: 可选TFA、HAc、HCl或其它
储存条件:负80℃至负20℃
