2426685-25-6
2024/12/16 14:53:25
TPP-1 是 PD-1/PD-L1 相互作用的有效抑制剂。TPP-1 与 PD-L1 特异性高亲和力结合 (KD=95 nM)。动物模型中，TPP-1 通过再激活 T 细胞功能抑制肿瘤生长。
TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1。
TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation。
单字母H2N-SGQYASYHCWCWR-DPGRSGGSK-OH
CAS号：2426685-25-6
多字母 H2N-Ser-Gly-Gln-Tyr-Ala-Ser-Tyr-His-Cys-Trp-Cys-Trp-Arg-Asp-Pro-Gly-Arg-Ser-Gly-Gly-Ser-Lys-OH
氨基酸个数 22
分子式 C107H150N34O32S2
平均分子量(MW) 2488.67
精确分子量(Exact Mass)(MW) 2487.06
等电点(PI) 12.53
pH=7.0时的净电荷数 7.15
GRAVY -1.2
亲水残基比例 0.04
消光系数 13980
溶解建议疏水
