1208862-61-6
2024/12/16 14:41:59
H-Ile-Pro-Pro-OH hydrochloride 是一种乳源三肽，抑制血管紧张素转换酶(ACE) ，IC50 为 5 μM。具有抗高血压效果。
Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)
Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats[1]
Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) [1].
Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].
单字母H2N-IPP-OH
CAS No. : 1208862-61-6
多字母 H2N-Ile-Pro-Pro-OH
氨基酸个数 3
分子式 C16H27N3O4
平均分子量(MW) 325.4
精确分子量(Exact Mass)(MW) 325.2
等电点(PI) -
pH=7.0时的净电荷数 0.97
GRAVY 0.43
亲水残基比例 -
消光系数 -
溶解建议疏水
参考文献：
【1】The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats【Hypertens Res. 2014 Aug;37(8):703-7. doi: 10.1038/hr.2014.72.】
【2】Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk【J Dairy Sci. 1995 Apr;78(4):777-83. doi: 10.3168/jds.S0022-0302(95)76689-9】
