1234319-68-6
2024/12/16 14:40:19
TAK-448 (MVT-602) 是一种有效的KISS1R激动剂，IC50 值为 460 pM，EC50 值为 632 pM。
TAK-448 (0.01-3 mg/kg; given i.h.; dosings on day 0 and 28) has greater anti-tumor effects in VCaP xenograft model[2]
序列：Ac-DTyr-Hyp-NTF-Aza-Gly-L-Arg(Me)-W-NH2
分子量：1225.36
Formula：C58H80N16O14
CAS 号：1234319-68-6
外观与性状:粉末状固体
消光系数: -
来源: 人工化学合成，仅限科学研究使用，不得用于人体。
储存条件:负80℃至负20℃
参考文献：
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility【doi: 10.1021/acs.jmedchem.6b00379】
Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitive prostate cancer model【doi: 10.1016/j.ejphar.2018.03.032】
