CaMK拮抗剂
2023/12/16 14:36:18
Calmodulin-Dependent Protein Kinase II (290-309) acetate 是有效的CaMK拮抗剂， 抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的 IC50 值为52 nM。
Peptide 290 to 309 is found to be a potent calmodulin antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase. Neither truncation from the amino terminus (peptide 296-309) nor extension in the carboxyl-terminal direction (peptide 294-319) markedly affects calmodulin binding, whereas shortening the peptide from the carboxyl terminus (peptide 290-302) or from both ends (peptide 295-304) results in the elimination of this activity
单字母H2N-LKKFNARRKLKGAILTTMLA-OH
多字母 H2N-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
氨基酸个数 20
分子式 C103H185N31O24S1
平均分子量(MW) 2273.83
精确分子量(Exact Mass)(MW) 2272.39
等电点(PI) -
pH=7.0时的净电荷数 6.97
GRAVY -0.01
亲水残基比例 -
消光系数 -
溶解建议亲水
参考文献：Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains
