KRpep-2d
2024/12/16 14:02:42
KRpep-2d (TFA) 是一种有效的K-Ras抑制剂，抑制 K-Ras 驱动的癌细胞增殖。KRpep-2d (TFA) 可用于癌症研究。
KRpep-2d (TFA) has cyclic structure with importance for K-Ras inhibitory activity. Leu77 , Ile9 , and Asp12 are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d[1].KRpep-2d (TFA) (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM)[1].
单字母：Ac-RRRRCPLYISYDP-VCRRRR-NH2(Disulfide Bridge:C5-C15)
多字母：Ac-Arg-Arg-Arg-Arg-Cys-Pro-Leu-Tyr-Ile-Ser-Tyr-Asp-Pro-Val-Cys-Arg-Arg-Arg-Arg-NH2(Disulfide Bridge:Cys5-Cys15)
氨基酸个数：19
分子式：C108H182O25N44S2
平均分子量(MW)：2561.01
精确分子量(Exact Mass)(MW)：2559.38
等电点(PI)：13.35
pH=7.0时的净电荷数：10.94
GRAVY：-1.46
亲水残基比例：0.05
消光系数：2980
溶解建议：亲水
参考文献：
[1]. Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761【DOI: 10.1016/j.bmcl.2017.04.063】
