Spantide I TFA 是substance P 的类似物，是选择性的神经激肽-1受体 (NK1 receptor) 的拮抗剂，其对NK1 和NK2 受体的Ki 值分别为 230 nM 和8150 nM。Spantide I可减少感染角膜的1型细胞因子和增强2型细胞因子IL-10，从而显著减少角膜穿孔。 Spantide I (50 and 100 nM perfused through the cerebral ventricles) causes a complete respiratory arrest in all of the examined animals.Spantide I (36 μg/mouse, ip daily) significantly decreases the number of perforated corneas, bacterial counts, and PMNs. Spantide I also downregulates the mRNA levels for type I cytokines (e.g., IFN-γ) as well as MIP-2, IL-6, TNF-α, and IL-1β. 单字母：H2N-rPKPQQwFwLL-NH2 多字母：H2N-DArg-Pro-Lys-Pro-Gln-Gln-DTrp-Phe-DTrp-Leu-Leu-NH2 氨基酸个数：11 分子式：C75H108N20O13 平均分子量(MW)：1497.79 精确分子量(Exact Mass)(MW)：1496.84 等电点(PI)：- pH=7.0时的净电荷数：2.97 GRAVY：-0.91 亲水残基比例：- 消光系数：11000 溶解建议：疏水 参考文献： Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection【DOI: 10.1167/iovs.06-0882】
