LXW7 是一种含 Arg-Gly-Asp (RGD) 的环状肽，是一种整合素αvβ3抑制剂，对αvβ3整联蛋白具有很高的结合亲和力，IC50 为 0.68 μM。LXW7 可增强 VEGFR-2 磷酸化和 ERK1/2 活化。具有抗炎活性。
LXW7 specially binds to αvβ3 integrin (Kd=76±10 nM). LXW7 binds strongly to αvβ3-K562 cells, weakly to αvβ5-K562 cells and αIIbβ3-K562 cells, and no binding to K562 cells. LXW7 has great potential as a highly efficient peptide ligand for targeted imaging and drug delivery。
LXW7 acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand。
单字母 H2N-CGRGDDVC-CONH2(Disulfide Bridge:C1-C8)
CAS No. : 1313004-77-1
多字母 H2N-Cys-Gly-Arg-Gly-Asp-Asp-Val-Cys-CONH2(Disulfide Bridge:Cys1-Cys8)
氨基酸个数 8
分子式 C29H48N12O12S2
平均分子量(MW) 820.89
精确分子量(Exact Mass)(MW) 820.3
等电点(PI) 8.84
pH=7.0时的净电荷数 1.91
GRAVY -0.39
亲水残基比例 0.2
消光系数 -
溶解建议 亲水
参考文献：
Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration【DOI: 10.1021/acschembio.7b00118】
