Yp537 是雌激素受体(ER)抑制剂，可阻止人类雌激素受体的二聚。
Yp537 (5-50 μM; 1 h) abolishes the formation of the hER-ERE complex. And dose not inhibit the formation of the STAT1-serum-induced element complex.
Yp537 binds to a SH2-like domain, and interferes with the SH2-like phosphopeptide coupling mechanism between hER monomers。
单字母 H2N-CNVVPL-pTyr-DLLLE-OH
CAS No. : 166664-90-0
多字母 H2N-Cys-Asn-Val-Val-Pro-Leu-Tyr(PO3H2)-Asp-Leu-Leu-Leu-Glu-OH
氨基酸个数 12
分子式 C64H104N13O22S1P1
平均分子量(MW) 1470.62
精确分子量(Exact Mass)(MW) 1469.69
等电点(PI) 6.28
pH=7.0时的净电荷数 -0.05
GRAVY 1.27
亲水残基比例 0.07
消光系数 1490
溶解建议 疏水
