褪黑素(Met¹⁸⁶)-Melanocyte Protein PMEL 17 (185-193)
编号：143583
CAS号：181477-43-0
三字母：H2N-Ile-Met-Asp-Gln-Val-Pro-Phe-Ser-Val-OH
描 述：Modified sequence of the gp100 epitope gp(209-217) ITDQVPFSV, in which a methionine replaced the natural threonine at position 2, bound to the HLA-A2 molecule with greater affinity than the unmodified peptide and was shown to have an increased ability to generate melanoma-reactive cytotoxic T lymphocytes (CTLs) in vitro when used for sensitization of peripheral blood mononuclear cells. IMDQVPFSV hold promise for the development of novel cancer immunotherapies.
gp100表位gp(209-217) ITDQVPFSV的修饰序列，其中蛋氨酸取代了2号位置的天然苏氨酸，与未修饰的肽相比，以更大的亲和力结合到HLA-A2分子上，并且在体外用于外周血单核细胞致敏时，显示出提高了产生黑色素瘤反应性细胞毒性T淋巴细胞(ctl)的能力。IMDQVPFSV有望开发新的癌症免疫疗法。
