1、CRGDCL
单字母 H2N-CRGDCL-OH(Disulfide Bridge:C1-C5)
多字母 H2N-Cys-Arg-Gly-Asp-Cys-Leu-OH(Disulfide Bridge:Cys1-Cys5)
氨基酸个数 6
分子式 C24H41N9O9S2
平均分子量(MW) 663.77
2、GACRGDCLGA
单字母 H2N-GACRGDCLGA-OH(Disulfide Bridge:C3-C7)
多字母 H2N-Gly-Ala-Cys-Arg-Gly-Asp-Cys-Leu-Gly-Ala-OH(Disulfide Bridge:Cys3-Cys7)
氨基酸个数 10
分子式 C34H57N13O13S2
平均分子量(MW) 920.03
3、CRRETAWAC
单字母 H2N-CRRETAWAC-OH(Disulfide Bridge:C1-C9)
多字母 H2N-Cys-Arg-Arg-Glu-Thr-Ala-Trp-Ala-Cys-OH(Disulfide Bridge:Cys1-Cys9)
氨基酸个数 9
分子式 C44H68N16O13S2
平均分子量(MW) 1093.24
4、GACRRETAWACGA
单字母 H2N-GACRRETAWACGA-OH(Disulfide Bridge:C3-C11)
多字母 H2N-Gly-Ala-Cys-Arg-Arg-Glu-Thr-Ala-Trp-Ala-Cys-Gly-Ala-OH(Disulfide Bridge:Cys3-Cys11)
氨基酸个数 13
分子式 C54H84N20O17S2
平均分子量(MW) 1349.5
参考文献：E. Koivunen, D.A. Gay, E. Ruoslahti, Selection of peptides binding to the alpha 5 beta 1 integrin from phage display library, J. Biol. Chem. 268 (1993) 20205–20210.
E. Koivunen, B. Wang, E. Ruoslahti, Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library, J. Cell Biol. 124 (1994) 373–380.
α6β1整合素靶向结合肽：VSWFSRHRYSPFAVS
单字母 H2N-VSWFSRHRYSPFAVS-OH
多字母 H2N-Val-Ser-Trp-Phe-Ser-Arg-His-Arg-Tyr-Ser-Pro-Phe-Ala-Val-Ser-OH
氨基酸个数 15
分子式 C86H120N24O21
平均分子量(MW) 1826.02
参考文献：O. Murayama, H. Nishida, K. Sekiguchi, Novel peptide ligands for integrin alpha 6 beta 1 selected from a phage display library, J. Biochem. (Tokyo) 120 (1996) 1841 445–451.
αvβ3/αvβ5：CDCRGDCFC (RGD-4C)
αvβ6整合素靶向结合肽：
1、RTDLDSLRTYTL
单字母 H2N-RTDLDSLRTYTL-OH
多字母 H2N-Arg-Thr-Asp-Leu-Asp-Ser-Leu-Arg-Thr-Tyr-Thr-Leu-OH
氨基酸个数 12
分子式 C62H104N18O22
平均分子量(MW) 1453.6
参考文献：S. Kraft, B. Diefenbach, R. Mehta, A. Jonczyk, G.A. Luckenbach, S.L. Goodman, Definition of an unexpected ligand recognition motif for alphav beta6 integrin, J. Biol. Chem. 274 (1999) 1979–1985.
2、SPRGDLAVLGHK
单字母 H2N-SPRGDLAVLGHK-OH
多字母 H2N-Ser-Pro-Arg-Gly-Asp-Leu-Ala-Val-Leu-Gly-His-Lys-OH
氨基酸个数 12
分子式 C54H92N18O16
平均分子量(MW) 1249.42
参考文献：E.M. Nothelfer, S. Zitzmann-Kolbe, R. Garcia-Boy, S. Kramer, C. Herold-Mende, A.Altmann, M. Eisenhut, W. Mier, U. Haberkorn, Identification and characterization of a peptide with affinity to head and neck cancer, J. Nucl. Med. 50 (2009) 426–434.
3、SPRGDLAVLGHKY
单字母 H2N-SPRGDLAVLGHKY-OH
多字母 H2N-Ser-Pro-Arg-Gly-Asp-Leu-Ala-Val-Leu-Gly-His-Lys-Tyr-OH
氨基酸个数 13
分子式 C63H101N19O18
平均分子量(MW) 1412.59
参考文献：E.M. Nothelfer, S. Zitzmann-Kolbe, R. Garcia-Boy, S. Kramer, C. Herold-Mende, A.Altmann, M. Eisenhut, W. Mier, U. Haberkorn, Identification and characterization of a peptide with affinity to head and neck cancer, J. Nucl. Med. 50 (2009) 426–434.
α4β1靶向结合肽：CPLDIDFYC
单字母 H2N-CPLDIDFYC-OH(Disulfide Bridge:C1-C9)
多字母 H2N-Cys-Pro-Leu-Asp-Ile-Asp-Phe-Tyr-Cys-OH(Disulfide Bridge:Cys1-Cys9)
氨基酸个数 9
分子式 C49H67N9O15S2
平均分子量(MW) 1086.24
α5β1靶向结合肽：CPIEDRPMC
单字母 H2N-CPIEDRPMC-OH(Disulfide Bridge:C1-C9)
多字母 H2N-Cys-Pro-Ile-Glu-Asp-Arg-Pro-Met-Cys-OH(Disulfide Bridge:Cys1-Cys9)
氨基酸个数 9
分子式 C42H68N12O14S3
平均分子量(MW) 1061.26
参考文献：K. Kelly, H. Alencar, M. Funovics, U. Mahmood, R. Weissleder, Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide, Cancer Res. 64 (2004) 6247–6251.
αvβ3靶向结合肽：CQQSNRGDRKRC
单字母 H2N-CQQSNRGDRKRC-OH(Disulfide Bridge:C1-C12)
多字母 H2N-Cys-Gln-Gln-Ser-Asn-Arg-Gly-Asp-Arg-Lys-Arg-Cys-OH(Disulfide Bridge:Cys1-Cys12)
氨基酸个数 12
分子式 C53H93N25O19S2
平均分子量(MW) 1448.59
参考文献：H. Witt, K. Hajdin, K. Iljin, O. Greiner, F.K. Niggli, B.W. Schafer, M. Bernasconi, Identification of a rhabdomyosarcoma targeting peptide by phage display with sequence similarities to the tumour lymphatic-homing peptide LyP-1, Int. J. Cancer 124 (2009) 2026–2032.
α2bβ3靶向结合肽：RGDGSSV
单字母 H2N-RGDGSSV-OH
多字母 H2N-Arg-Gly-Asp-Gly-Ser-Ser-Val-OH
氨基酸个数 7
分子式 C25H44N10O12
平均分子量(MW) 676.68
参考文献：D. Hallahan, L. Geng, S. Qu, C. Scarfone, T. Giorgio, E. Donnelly, X. Gao, J. Clanton,Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels,Cancer Cell 3 (2003) 63–74.
α3β1b靶向结合肽：SWKLPPS
单字母 H2N-SWKLPPS-OH
多字母 H2N-Ser-Trp-Lys-Leu-Pro-Pro-Ser-OH
氨基酸个数 7
分子式 C39H59N9O10
平均分子量(MW) 813.94
参考文献 :N. Akita, F. Maruta, L.W. Seymour, D.J. Kerr, A.L. Parker, T. Asai, N. Oku, J. Nakayama,S. Miyagawa, Identification of oligopeptides binding to peritoneal tumors of gastric cancer, Cancer Sci. 97 (2006) 1075–1081.
αvβ3 αvβ5靶向结合肽：CRGDKRGPDC (iRGD)
单字母 H2N-CRGDKRGPDC-OH(Disulfide Bridge:C1-C10)
多字母 H2N-Cys-Arg-Gly-Asp-Lys-Arg-Gly-Pro-Asp-Cys-OH(Disulfide Bridge:Cys1-Cys10)
氨基酸个数 10
分子式 C41H69N17O15S2
平均分子量(MW) 1104.22
参考文献：K.N. Sugahara, T. Teesalu, P.P. Karmali, V.R. Kotamraju, L. Agemy, O.M. Girard, D. Hanahan, R.F. Mattrey, E. Ruoslahti, Tissue-penetrating delivery of compounds and nanoparticles into tumors, Cancer Cell 16 (2009) 510–520
