864084-88-8
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Opiorphin 是一种阿片类肽，是一种强效的人脑啡肽失活锌异肽酶抑制剂。Opiorphin 抑制两种脑啡肽分解外酶，人中性外肽内源性肽酶 hNEP (EC 3.4.24.11)和人外氨基肽酶 hAP-N (EC 3.4.11.2)。Opiorphin 通过激活内源性阿片依赖性传递显示出强大的镇痛活性。
Opiorphin (1-100 μM; the mouse isolated colon) causes contractile effects in mouse distal colon in a concentration-dependent manner and enhances the contractile response induced by Met-enkephalin。
Opiorphin (0-50 μM; hNEP or hAP-N transformed HEK293 cell line) is a dual inhibitor of enkephalin-degrading hNEP and hAP-N in vitro. Opiorphin inhibits Mca-BK2 endoproteolysis by the cell-surface recombinant hNEP with an IC50 value of 33 μM. and inhibits the Ala-pNA cleavage by hAP-N with an IC50 value of 65 μM。
编号:413380
中文名称: Opiorphin trifluoroacetate salt
CAS号: 864084-88-8
单字母: H2N-QRFSR-OH
三字母: H2N-Gln-Arg-Phe-Ser-Arg-OH
氨基酸个数: 5
分子式: C29H48N12O8
平均分子量: 692.77
精确分子量: 692.37
等电点(PI): -
pH=7.0时的净电荷数: 2.97
平均亲水性: 0.8
疏水性值: -2.1
消光系数:-
