848644-86-0
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HSDVHK-NH2 是整合素αvβ3-玻璃体结合蛋白的互作抑制剂，其 IC50 值为 1.74 pg/mL (2.414 pM)。
HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group。
The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM。
HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression。
单字母H2N-HSDVHK-NH2
CAS号：848644-86-0
多字母 H2N-His-Ser-Asp-Val-His-Lys-NH2
氨基酸个数 6
分子式 C30H48N12O9
平均分子量(MW) 720.78
精确分子量(Exact Mass)(MW) 720.37
等电点(PI) 9.71
pH=7.0时的净电荷数 1.45
GRAVY -1.73
亲水残基比例 0.13
消光系数 -
溶解建议亲水
